WATER SOLUBLE NANOPARTICLES INCLUSION COMPLEXES

摘要

Nano-dispersions of water-soluble and stable nano-sized particlesare provided comprising hydrophilic inclusion complexes of an active compound in a non-crystalline state surrounded by and entrapped within an amphiphilic polymer. The inclusion complex is stabilized by non-valent interactions between the active compound and the polymer. The following pairs of active compound/amphiphilic polymers are provided: (i) azithromycin/ a polysaccharide or polyvinyl alcohol, or clarithromycin/alginate or chitosan; (ii) donepezil hydrochloride/ a polysaccharide; (iii) an azole compound/a polysaccharide, polyacrylic acid, a copolymer of polyacrylic acid, polymethacrylic acid and a copolymer of polymethacrylic acid; and (iv) a taxane/gelatin.