ANTIBACTERIAL COMPOSITIONS

摘要

Antibacterial (alkyl)aminopyrrolizidine compounds for use in therapy or prophylaxis may be pharmaceutically acceptable derivatives of loline. Examples include 2,7-dihydroxy-l-methylaminopyrrolizidine, 2,7-dihydroxy-1-aminopyrrolizidine, 2-hydroxy-l-aminopyrrolizidine, 2-hydroxy-1-methylaminopyrrolizidine, 7-hydroxy-1-aminopyrrolizidine, 7-hydroxy-l-methylaminopyrrolizidine, 1alpha-methylamino-2beta-hydroxypyrrolizidine, lalpha-methylamino-7beta-hydroxypyrrolizidine, 1alpha-amino-2beta-hydroxypyrrolizidine, lalpha-amino-7beta-hydroxypyrrolizidine, 1alpha-amino-2,7beta-hydroxypyrrolizidine and lalpha-methylamino-2,7beta-hydroxypyrrolizidine. The compounds may be used to treat infection with MRSA, including C-MSRA1, C-MRSA2, C-MRSA3, C-MSRA4, Belgian MRSA, Swiss MRSA and any of the EMRSA strains.