| 摘要 |
<p>A novel piperidine derivative (I) which is either a compound represented by the formula (I) (wherein Ar represents an aryl, aralkyl, or aromatic heterocyclic group which may have one or more substituents; R1 represents hydrogen, an optionally substituted hydrocarbon group, acyl, or an optionally substituted heterocyclic group; X represents oxygen or optionally substituted imino; Z represents optionally substituted methylene; ring A represents a piperidine ring which may be further substituted; and ring B represents an optionally substituted aromatic ring; provided that when Z is methylene substituted by oxo, then R1 is not methyl and when Z is methylene substituted by methyl, then ring B is a substituted aromatic ring) or a salt of the compound. The derivative has excellent tachykinin receptor antagonistic activity and is useful in medicines, especially a preventive/therapeutic agent for frequent urination/urinary incontinence.</p> |
