MICROORGANISM PRODUCING TACROLIMUS AND MASS-PRODUCTIVE METHOD TACROLIMUS USING THE SAME

摘要

The present invention relates to a tacrolimus producing strain, more precisely, a Streptomyces clavuligerus strain mass-producing tacrolimus represented by formula 1 and a method for mass-production of tacrolimus by using the same. The strain of the present invention enables mass-production of highly qualified tacrolimus which can be used as an immunosuppressant, so that it can be effectively used for the preparation of a therapeutic agent for organ transplantation, Rh hemolytic disease of the newborn, autoimmune diseases, etc.