发明名称 |
GAS-FILLED MICROVESICLE ASSEMBLY FOR CONTRAST IMAGING |
摘要 |
<p>Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component - MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.</p> |
申请公布号 |
WO2005063305(A1) |
申请公布日期 |
2005.07.14 |
申请号 |
WO2004IB04230 |
申请日期 |
2004.12.21 |
申请人 |
BRACCO RESEARCH SA;SCHNEIDER, MICHEL;BUSSAT, PHILIPPE;YAN, FENG;SENENTE, ANNE |
发明人 |
SCHNEIDER, MICHEL;BUSSAT, PHILIPPE;YAN, FENG;SENENTE, ANNE |
分类号 |
A61K41/00;A61K47/48;A61K49/22;A61K51/12;(IPC1-7):A61K49/22 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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