发明名称 |
MODIFIED CPG OLIGODEOXYNUCLEOTIDE WITH IMPROVED IMMUNOREGULATORY FUNCTION |
摘要 |
<p>The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3'-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anticancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3'-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.</p> |
申请公布号 |
KR20050072992(A) |
申请公布日期 |
2005.07.13 |
申请号 |
KR20040001161 |
申请日期 |
2004.01.08 |
申请人 |
YONSEI UNIVERSITY |
发明人 |
KIM, SOO KIE;PARK, SEUNG KYU;PARK, SOO JUNG;CHO, HYUN CHUL |
分类号 |
C12N15/09;A61K31/712;A61K39/29;A61K39/39;A61P1/16;A61P31/20;A61P35/00;C07H21/04;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|