| 发明名称 | 钠－氢交换剂1型抑制剂晶体 | ||
| 摘要 | 式(I)的NHE－1抑制剂晶体，使用这种NHE－1抑制剂晶体的方法及包含这种NHE－1抑制剂晶体的药物组合物。NHE－1抑制剂晶体可用于减少因组织缺血引起的组织损伤。 | ||
| 申请公布号 | CN1636991A | 申请公布日期 | 2005.07.13 |
| 申请号 | CN200410094665.X | 申请日期 | 2000.10.09 |
| 申请人 | 辉瑞产品公司 | 发明人 | 莱尔·R·布罗斯特罗姆;特伦斯·J·康诺利;李征;苏珊·L·奥里尔;巴雷特·K·沙 |
| 分类号 | C07D401/04;//(C07D401/04,231∶12,215∶02) | 主分类号 | C07D401/04 |
| 代理机构 | 北京市柳沈律师事务所 | 代理人 | 张平元;赵仁临 |
| 主权项 | 1.一种具有式(I)的盐形式的晶体<img file="A2004100946650002C1.GIF" wi="806" he="598" />其中该晶体选自：晶形C阳极：CU-波长1：1.54056 波长2：1.54439(Rel强度：0.500)范围#1-偶合：3.000至40.000 步长：0.040 步时：1.00平滑的宽度：0.300 临界值：1.0<tables id="table1" num="001"><table width="776"><tgroup cols="6"><colspec colname="c001" colwidth="20%" /><colspec colname="c002" colwidth="15%" /><colspec colname="c003" colwidth="18%" /><colspec colname="c004" colwidth="16%" /><colspec colname="c005" colwidth="19%" /><colspec colname="c006" colwidth="12%" /><thead><row><entry morerows="1"> d(_)</entry><entry morerows="1"> l(rel)</entry><entry morerows="1"> d(_)</entry><entry morerows="1"> l(rel)</entry><entry morerows="1"> d(_)</entry><entry morerows="1"> l(rel)</entry></row></thead><tbody><row><entry morerows="1"> 23.84363</entry><entry morerows="1"> 3.0</entry><entry morerows="1"> 6.20370</entry><entry morerows="1"> 8.0</entry><entry morerows="1"> 4.39823</entry><entry morerows="1"> 21.9</entry></row><row><entry morerows="1"> 12.75285</entry><entry morerows="1"> 26.7</entry><entry morerows="1"> 5.99047</entry><entry morerows="1"> 16.8</entry><entry morerows="1"> 4.25862</entry><entry morerows="1"> 15.7</entry></row><row><entry morerows="1"> 11.42066</entry><entry morerows="1"> 5.6</entry><entry morerows="1"> 5.74421</entry><entry morerows="1"> 12.1</entry><entry morerows="1"> 4.11140</entry><entry morerows="1"> 6.0</entry></row><row><entry morerows="1"> 10.47264</entry><entry morerows="1"> 100</entry><entry morerows="1"> 5.43344</entry><entry morerows="1"> 17.7</entry><entry morerows="1"> 3.98950</entry><entry morerows="1"> 78.6</entry></row><row><entry morerows="1"> 9.13265</entry><entry morerows="1"> 1.9</entry><entry morerows="1"> 5.18281</entry><entry morerows="1"> 8.5</entry><entry morerows="1"> 3.81556</entry><entry morerows="1"> 8.6</entry></row><row><entry morerows="1"> 8.46986</entry><entry morerows="1"> 18.7</entry><entry morerows="1"> 5.07621</entry><entry morerows="1"> 4.8</entry><entry morerows="1"> 3.70622</entry><entry morerows="1"> 13.3</entry></row><row><entry morerows="1"> 8.04025</entry><entry morerows="1"> 35.7</entry><entry morerows="1"> 4.89018</entry><entry morerows="1"> 13.8</entry><entry morerows="1"> 3.60428</entry><entry morerows="1"> 8.4</entry></row><row><entry morerows="1"> 7.37462</entry><entry morerows="1"> 5.9</entry><entry morerows="1"> 4.78821</entry><entry morerows="1"> 9.9</entry><entry morerows="1"> 3.56411</entry><entry morerows="1"> 15.8</entry></row><row><entry morerows="1"> 6.89800</entry><entry morerows="1"> 12.8</entry><entry morerows="1"> 4.71228</entry><entry morerows="1"> 11.1</entry><entry morerows="1"> 3.50634</entry><entry morerows="1"> 14.5</entry></row><row><entry morerows="1"> 6.74243</entry><entry morerows="1"> 7.2</entry><entry morerows="1"> 4.64604</entry><entry morerows="1"> 11.8</entry><entry morerows="1"> 3.45643</entry><entry morerows="1"> 22.6</entry></row><row><entry morerows="1"> 6.38235</entry><entry morerows="1"> 13.6</entry><entry morerows="1"> 4.47029</entry><entry morerows="1"> 14.6</entry><entry morerows="1"> 3.38053</entry><entry morerows="1"> 10.5</entry></row></tbody></tgroup></table></tables><tables id="table2" num="002"><table width="535"><tgroup cols="4"><colspec colname="c001" colwidth="29%" /><colspec colname="c002" colwidth="21%" /><colspec colname="c003" colwidth="27%" /><colspec colname="c004" colwidth="23%" /><thead><row><entry morerows="1"> d(_)</entry><entry morerows="1"> l(rel)</entry><entry morerows="1"> d(_)</entry><entry morerows="1"> l(rel)</entry></row></thead><tbody><row><entry morerows="1"> 3.27809</entry><entry morerows="1"> 15.2</entry><entry morerows="1"> 2.67907</entry><entry morerows="1"> 5.1</entry></row><row><entry morerows="1"> 3.13075</entry><entry morerows="1"> 17.6</entry><entry morerows="1"> 2.63333</entry><entry morerows="1"> 4.0</entry></row><row><entry morerows="1"> 3.09826</entry><entry morerows="1"> 9.4</entry><entry morerows="1"> 2.58530</entry><entry morerows="1"> 6.0</entry></row><row><entry morerows="1"> 3.05034</entry><entry morerows="1"> 6.9</entry><entry morerows="1"> 2.50819</entry><entry morerows="1"> 3.7</entry></row><row><entry morerows="1"> 2.98350</entry><entry morerows="1"> 7.9</entry><entry morerows="1"> 2.46620</entry><entry morerows="1"> 6.4</entry></row><row><entry morerows="1"> 2.91868</entry><entry morerows="1"> 5.5</entry><entry morerows="1"> 2.43972</entry><entry morerows="1"> 4.6</entry></row><row><entry morerows="1"> 2.87199</entry><entry morerows="1"> 4.6</entry><entry morerows="1"> 2.38677</entry><entry morerows="1"> 4.7</entry></row><row><entry morerows="1"> 2.81359</entry><entry morerows="1"> 5.5</entry><entry morerows="1"> 2.33708</entry><entry morerows="1"> 4.3</entry></row><row><entry morerows="1"> 2.74383</entry><entry morerows="1"> 5.0</entry><entry morerows="1"> 2.31420</entry><entry morerows="1"> 3.9</entry></row><row><entry morerows="1"> 2.70966</entry><entry morerows="1"> 3.2</entry><entry morerows="1"> 2.29162</entry><entry morerows="1"> 3.3</entry></row></tbody></tgroup></table></tables>。 | ||
| 地址 | 美国康涅狄格州 | ||