| 摘要 |
This invention provides small-sized, intrabuccally rapidly disintegrating tablets comprising D-mannitol having an average particle diameter of 31 mu m to 80 mu m, an active ingredient, a disintegrant and stearic acid or a metallic stearate of 0.01 % by weight to 0.5 % by weight, which have sufficient hardness, do not disintegrate during usual handling, and have a good disintegrability in the oral cavity and a pleasant feeling in a mouth when administered, and further provides a method for producing an intrabuccally rapidly disintegrating tablet containing stearic acid or a metallic stearate in an amount of 0.01 % by weight to 0.5 % by weight, which comprises consecutively tableting a powder material containing D-mannitol having an average particle diameter of 31 mu m to 80 mu m, an active ingredient and a disintegrant by an external lubricating compression method, during which stearic acid or a metallic stearate as a lubricant is previously sprayed to adhere onto the punches and the dies of the tableting machine and the unadherent surplus of stearic acid or a metallic stearate is recovered.
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