| 发明名称 |
alpha-arylethylpiperazine derivatives as neurokinin antagonists |
| 摘要 |
The invention relates to new alpha-arylethylpiperazine of the formula wherein Z represents 0 or S; n' represents 1 or 2; R<SUP>2 </SUP>represents a hydrogen atom or a methyl group; W, Ar<SUP>1 </SUP>and Ar<SUP>2 </SUP>represent various substituents as defined herein; or non-toxic pharmaceutically acceptable salt, individual optical isomer, or individual diastereoisomer thereof, which are useful as neurokinin receptor antagonists (NK<SUB>1 </SUB>antagonists). It also relates to processes for their preparation and use in methods for treatment of asthma and/or allergic rhinitis.
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| 申请公布号 |
US6916797(B2) |
申请公布日期 |
2005.07.12 |
| 申请号 |
US20020168331 |
申请日期 |
2002.08.30 |
| 申请人 |
UCB, S.A. |
发明人 |
STIERNET FRANCOISE;GENICOT CHRISTOPHE;LASSOIE MARIE-AGNES;MOUREAU FLORENCE;RYCKMANS THOMAS;TAVERNE THIERRY;HENICHART JEAN-PIERRE;NEUWELS MICHEL;GOLDSTEIN SOLO |
| 分类号 |
C07D249/08;A61K31/495;A61K31/496;A61K31/5375;A61K31/662;A61P11/02;A61P11/06;A61P29/00;A61P37/08;A61P43/00;C07D209/34;C07D209/48;C07D213/36;C07D213/38;C07D257/04;C07D295/08;C07D295/088;C07D295/13;C07D295/15;C07D307/52;C07D307/87;C07D333/20;C07D333/72;C07F9/6509;(IPC1-7):A61K31/495;C07F9/650;C07D295/155 |
主分类号 |
C07D249/08 |
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