发明名称 |
Method of treatment of dopamine-related dysfunction |
摘要 |
The present invention relates to the treatment of dopamine-related dysfunction using full D<SUB>1 </SUB>dopamine receptor agonists in an intermittent dosing protocol with a short, but essential, "off-period." The D<SUB>1 </SUB>agonist concentration is reduced during the "off-period" to obtain a plasma concentration of agonist that suboptimally activates D<SUB>1 </SUB>dopamine receptors for a period of time to prevent induction of tolerance. Specifically, the method comprises the steps of periodically administering to a patient a full D<SUB>1 </SUB>agonist with a half-life of up to about 6 hours at a dose resulting in a first plasma concentration of agonist capable of activating D<SUB>1 </SUB>dopamine receptors to produce a therapeutic effect. The dose is reduced at least once every 24 hours to obtain a second lower plasma concentration of agonist that results in suboptimal activation of D<SUB>1 </SUB>dopamine receptors for a period of time sufficient to prevent induction of tolerance.
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申请公布号 |
US6916823(B2) |
申请公布日期 |
2005.07.12 |
申请号 |
US20020050289 |
申请日期 |
2002.01.16 |
申请人 |
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
MAILMAN RICHARD B.;NICHOLS DAVID E.;HUANG XUEMEI |
分类号 |
C07D221/18;A61K9/08;A61K9/10;A61K9/20;A61K9/48;A61K9/50;A61K31/00;A61K31/473;A61K31/4741;A61K45/00;A61K45/06;A61K47/02;A61K47/12;A61K47/22;A61K47/24;A61P1/08;A61P9/02;A61P9/04;A61P9/06;A61P9/12;A61P15/10;A61P25/00;A61P25/14;A61P25/16;A61P25/18;A61P25/28;A61P43/00;C07D491/06;(IPC1-7):A61K31/44 |
主分类号 |
C07D221/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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