发明名称 ANTI-AMYLOID BETA ANTIBODIES AND THEIR USE
摘要 The present invention relates to antibody molecules capable of specifically recognizing two regions of the ²-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
申请公布号 PL372269(A1) 申请公布日期 2005.07.11
申请号 PL20030372269 申请日期 2003.02.20
申请人 F.HOFFMANN-LA ROCHE AG;MORPHOSYS AG 发明人 BARDROFF MICHAEL;BOHRMANN BERND;BROCKHAUS MANFRED;HUBER WALTER;KRETZSCHMAR TITUS;LOEHNING CORINNA;LOETSCHER HANSRUEDI;NORDSTEDT CHRISTER;ROTHE CHRISTINE
分类号 C12N15/09;A61K39/00;A61K39/395;A61P25/00;A61P25/28;C07K14/47;C07K16/18;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08;G01N33/68 主分类号 C12N15/09
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