| 摘要 |
In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: <?in-line-formulae description="In-line Formulae" end="lead"?>D-L-S (1) <?in-line-formulae description="In-line Formulae" end="tail"?> or formula 2: <?in-line-formulae description="In-line Formulae" end="lead"?>D-L-S' (2) <?in-line-formulae description="In-line Formulae" end="tail"?> wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S' is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase.
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