ANTIBODIES AGAINST SARS-CoV AND METHODS OF USE THEREOF
摘要
The invention provides scFv antibodies and monoclonal antibodies that neutralize SARS-CoV. Also provided are methods of treating and/or preventing a coronavirus-related disease or disorder such as SARS. The invention also provides methods of vaccinating a patient against SARS-CoV. Also provided are methods of diagnosing coronavirus-related or disorders and methods of detecting the presence of a coronavirus in a sample. The invention additionally provides methods of screening for compounds that modulate the binding of SARS-CoV and the SARS-CoV receptor ACE2 as well as for compounds useful to treat SARS-CoV-related diseases or disorders.
申请公布号
WO2005060520(A2)
申请公布日期
2005.07.07
申请号
WO2004US39750
申请日期
2004.11.24
申请人
DANA-FARBER CANCER INSTITUTE, INC.;MARASCO, WAYNE;SUI, JIANHUA