<p>Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.</p>
申请公布号
CA2545696(A1)
申请公布日期
2005.07.07
申请号
CA20042545696
申请日期
2004.11.23
申请人
ONYX PHARMACEUTICALS, INC.
发明人
FATTAEY, ALI;SHEN, JERRY YUQIAO;LAQUERRE, SYLVIE;JOHNSON, LEISA;HERMISTON, TERRY
