发明名称 |
3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS |
摘要 |
The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula 1: (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis. |
申请公布号 |
WO2005060665(A2) |
申请公布日期 |
2005.07.07 |
申请号 |
WO2004US42321 |
申请日期 |
2004.12.16 |
申请人 |
INCYTE CORPORATION;XUE, CHU-BIAO;METCALF, BRIAN;HAN, AMY QI;ROBINSON, DARIUS, J.;ZHENG, CHANGSHENG;WANG, ANLAI;ZHANG, YINGXIN |
发明人 |
XUE, CHU-BIAO;METCALF, BRIAN;HAN, AMY QI;ROBINSON, DARIUS, J.;ZHENG, CHANGSHENG;WANG, ANLAI;ZHANG, YINGXIN |
分类号 |
A61K31/4025;A61K31/427;A61K31/44;A61K31/4439;A61K31/506;C07D401/12;C07D401/14;C07D417/02 |
主分类号 |
A61K31/4025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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