QUANTIFICATION AND GENERATION OF IMMUNE SUPPRESSIVE EXOSOMES

摘要

Methods of identifying and quantifying immune suppressive factors in biological fluids of cancer patients comprising purification and assessment of small (60-250nm ) microvesicles are disclosed. Said microvesicles can serve alone, or in combination with other immunological assays as a prognastic indicator for a cancer patient, o r alternatively as a determinant for various immunological and non-immunological therapeutic interventions. Methods of generating immune suppressive exosomes are also described.