A process for synthesizing highly lipophilic derivatives of camptothecin. Th e process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reacti on to produce 7-substituted derivatives of camptothecin.
申请公布号
CA2548543(A1)
申请公布日期
2005.07.07
申请号
CA20042548543
申请日期
2004.11.01
申请人
BIONUMERIK PHARMACEUTICALS, INC.
发明人
WANG, JIANYAN;KOCHAT, HARRY;NARKUNAN, KESAVARAM;WU, YE