发明名称 |
A NEW ROUTE TO alpha-TOCOPHEROL, alpha-TOCOPHERYL ALKANOATES AND PRECURSORS THEREOF |
摘要 |
The present invention is concerned with a novel process for the manufacture of (E/Z)-4-alkanoyloxy-3,5,6-trimethyl-2-phytylphenyI esters and silyl ethers, precursors of alpha- tocopherol and alpha-tocopheryl alkanoates, by cross-metathesis reaction of 2-alkenyl-3,5,6-trimethylhydroquinone dialkanoates or 4-alkanoyloxy-2-alkenyl-3,5,6-trimethylphenyI silylethers with 2,6,10,14-tetramethylpentadecene or a phytol derivative, e.g. phytyl acetate, in the presence of a cross-metathesis catalyst. As the cross-metathesis catalyst especially ruthenium metal carbene complexes are suitable which possess (a) ruthenium metal center(s), have an electron count of 16 or 18 and are penta- or hexa- coordinated. A further object of the invention is a process for the manufacture of alpha-tocopherol and alpha-tocopheryl alkanoates comprising this reaction. |
申请公布号 |
WO2005026181(A3) |
申请公布日期 |
2005.07.07 |
申请号 |
WO2004EP09748 |
申请日期 |
2004.09.02 |
申请人 |
DSM IP ASSETS B.V.;BONRATH, WERNER;BREUNINGER, MANFRED;MALAISE, GREGORY;NETSCHER, THOMAS |
发明人 |
BONRATH, WERNER;BREUNINGER, MANFRED;MALAISE, GREGORY;NETSCHER, THOMAS |
分类号 |
C07C67/293;C07C67/475;C07D311/72;C07F7/18 |
主分类号 |
C07C67/293 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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