METHODS OF ASSESSING THE RISK OF NON-TRAUMATIC BONE FRACTURE

摘要

The present invention relates to the identification of RANK ligand (RANKL) as associated with and useful as a marker of bone metabolism conditions and particularly of predicting risk of non­traumatic bone fractures. The invention also relates to assays, methods and kits comprising RANKL and/or antibodies thereto for screening, diagnosis, prediction and monitoring. This invention provides methods for determining a subject's risk of non-traumatic bone fracture, comprising determining the subject's level of RANKL, particularly of soluble uncomplexed RANKL.