| 摘要 |
<p>This invention discloses nucleic acid constructs and methods for targeting the integration of an exogenous nucleic acid molecule to a specific location within the genome of a host cell. More particularly, the present invention discloses targeting constructs and methods which permit the expression of a selectable marker gene when the exogenous nucleic acid molecule is integrated into the genome via site-specific homologous recombination but which inhibit or suppress the expression of the selectable marker gene when the exogenous nucleic acid molecule is integrated into the host cell genome via non-homologous recombination or random insertion.</p> |
