发明名称 |
Active hedgehog protein conjugate |
摘要 |
A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
|
申请公布号 |
US2005148510(A1) |
申请公布日期 |
2005.07.07 |
申请号 |
US20040961982 |
申请日期 |
2004.10.08 |
申请人 |
CURIS, INC. |
发明人 |
ESSWEIN ANGELIKA;LANG KURT;RUEGER PETRA;SEYTTER TILMAN |
分类号 |
C12N15/09;A61K38/00;A61P19/00;A61P21/00;A61P25/00;C07K14/435;C07K14/47;(IPC1-7):A61K38/17;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|