发明名称 |
Binding proteins as chemotherapy |
摘要 |
Embodiments of the invention include using molecular biology techniques to produce a fusion or chimeric protein of two or more different IGFBPs For example, the IGF binding properties or characteristics of a first protein are retained as is the receptor binding properties and characteristics of a second IGFBP. In particular aspects, a fusion or chimera of IGFBP-6 and IGFBP-3 (IGFBP-6/3) may be produced and used. Certain properties of each binding protein contribute to the therapeutic property of the fusion protein. For IGFBP-3 these properties include the specific binding to a target cell and the induction of apoptosis in a target cell. For IGFBP-6, these properties include an increased affinity for IGF-II versus IGF-I. The binding of IGF-II can deprive a cell exhibiting aberrant growth characteristics of the growth promoting functions of IGF-II.
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申请公布号 |
US2005148509(A1) |
申请公布日期 |
2005.07.07 |
申请号 |
US20040887229 |
申请日期 |
2004.07.08 |
申请人 |
THE US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
DAKE BRIAN;BOOTH BARBARA A.;BOES MARY;BAR ROBERT S. |
分类号 |
A61K31/4745;A61K31/522;A61K31/704;A61K31/7072;A61K38/00;A61K38/18;C07H21/04;C07K14/47;C07K14/475;C12Q1/68;(IPC1-7):A61K38/18;A61K31/707;A61K31/474 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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