发明名称 |
REDUCTION OF TOXICITY OF MULTI-TARGETING ANTIFOLATES |
摘要 |
<p>The use of tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, and at least one multi-targeting antifolate, for the manufacture of a pharmaceutical composition for the treatment of cancer is disclosed. By combining the multi-targeting anti-folate with tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, it is possible to remarkably reduce toxic side-effects without diminishing the anti-tumour action of the drugs. A pharmaceutical composition, a kit comprising the pharmaceutical composition as well as a method for the treatment of cancer are also disclosed.</p> |
申请公布号 |
WO2005060973(A1) |
申请公布日期 |
2005.07.07 |
申请号 |
WO2004SE01955 |
申请日期 |
2004.12.22 |
申请人 |
BIOFOL AB;GUSTAVSSON, BENGT;CARLSSON, GOERAN |
发明人 |
GUSTAVSSON, BENGT;CARLSSON, GOERAN |
分类号 |
A61K;A61K31/519;A61P35/00;(IPC1-7):A61K31/519 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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