A new process for the preparation of Ropinirole (1) and pharmaceutically acceptable hydrochloride salt thereof comprising reacting the compound (V) with nitromethane to obtain the compound of formula (II), which is reduced to compound (III) and alkylated to obtain compound (IV). The oxidation of the indole ring provides the compound of formula (I).
申请公布号
WO2005040115(A8)
申请公布日期
2005.07.07
申请号
WO2004EP11505
申请日期
2004.10.13
申请人
URQUIMA S.A.;BOSCH CARTES, JOAN;PUJOL OLLE, XAVIER;DEL RIO PERICACHO, JOSE LUIS;ALONSO MARIN, YOLANDA;BESSA SANCHEZ, MERCE
发明人
BOSCH CARTES, JOAN;PUJOL OLLE, XAVIER;DEL RIO PERICACHO, JOSE LUIS;ALONSO MARIN, YOLANDA;BESSA SANCHEZ, MERCE
