<p>Decomposition of iodonium salts by a free radical process has been identified as a significant factor in the observed yield variability of fluoridation reactions using said iodonium salts. Accordingly, the inclusion of a free radical trap in the reaction mixture blocks the radical chain decomposition pathway for iodonium salts such that only the reaction leading to fluoridation can occur and the yield of aryl fluoride becomes high and reproducible. The reaction may also be carried out on solid phase. In both the solution and the solid phase the preferred method of the present invention is radiofluoridation.</p>
申请公布号
WO2005061415(A1)
申请公布日期
2005.07.07
申请号
WO2004GB05304
申请日期
2004.12.17
申请人
GE HEALTHCARE LIMITED;WADSWORTH, HARRY, JOHN;WIDDOWSON, DAVID, ARTHUR;WILSON, EMMANUELLE;CARROLL, MICHAEL, ANDREW
发明人
WADSWORTH, HARRY, JOHN;WIDDOWSON, DAVID, ARTHUR;WILSON, EMMANUELLE;CARROLL, MICHAEL, ANDREW