HYDROXYPYRIMIDINONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

摘要

[PROBLEMS] To provide a novel compound having antiviral activity, especially HIV integrase inhibitory activity; and a medicine containing the compound, especially an anti-HIV drug. [MEANS FOR SOLVING PROBLEMS] The compound is a compound represented by the formula (I) [wherein X represents any of the following groups (a) (b) (c) (wherein ring C represents a nitrogenous aromatic heterocycle in which at least one of the atoms adjacent to the atom bonded to the pyrimidine ring is an unsubstituted nitrogen atom; R<10> represents hydrogen, etc.; and ring D represents aryl, etc.); Z<1> and Z<3> each represents a single bond, etc.; Z<2> represents a single bond, etc.; Ar represents optionally substituted aryl, etc.; and R<1> represents lower alkyl, etc. and R<2> represents hydrogen, etc., provided that R<1> and R<2> may form an optionally substituted heterocycle in cooperation with the adjacent atoms], a pharmaceutically acceptable salt of the compound, or a solvate of either.