| 发明名称 |
Compositions and methods for inhibition of phospholipase a2 mediated inflammation |
| 摘要 |
Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A<SUB>2 </SUB>(PLA<SUB>2</SUB>) activity are provided. A role for PLA<SUB>2 </SUB>activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA<SUB>2 </SUB>activity is provided.
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| 申请公布号 |
US2005148549(A1) |
申请公布日期 |
2005.07.07 |
| 申请号 |
US20050506059 |
申请日期 |
2005.02.18 |
| 申请人 |
DENNIS EDWARD;YAKSH TONY;LUCAS KARIN K.;SVENSSON CAMILLA;SIX DAVID A.;KOKOTOS GEORGE;CONSTANINOU-KOKOTOU VIOLETTA |
发明人 |
DENNIS EDWARD;YAKSH TONY;LUCAS KARIN K.;SVENSSON CAMILLA;SIX DAVID A.;KOKOTOS GEORGE;CONSTANINOU-KOKOTOU VIOLETTA |
| 分类号 |
C07D309/30;A61K31/16;A61K31/197;A61K31/22;A61K31/325;A61K31/366;A61K31/40;A61P25/04;A61P29/00;A61P43/00;C07C233/56;C07C235/74;C07C235/78;C07C235/80;C07C237/22;C07C271/12;C07C271/22;C07D207/08;(IPC1-7):A61K31/66;A61K31/195;A61K31/41;C07D257/04;C07F9/28;C07C233/46 |
主分类号 |
C07D309/30 |
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