发明名称 |
Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applicaions |
摘要 |
A biologic can be immobilized in a transparent polyurethane-hydrogel composition. Such a polyurethane-hydrogel composition can be prepared from forming a polyurethane-hydrogel mixture and immobilizing a biologic in the mixture. The mixture can be formed by admixing a prepolymer and a water-soluble crosslinker in aqueous solvent and in the substantial absence of organic solvent. A suitable prepolymer generally includes at least one water-soluble polyol and at least one isocyanate and can be added to the mixture in an amount of no greater than about 5 weight percent based on total weight of all components. A suitable crosslinker generally has a crosslinker functionality of at least 2. A biologic includes cells, peptides, nucleics, peptide nucleic acids, saccharides, lipopolysaccharides, glycolipids, and combinations of these. A polyurethane-hydrogel composition having an immobilized biologic can be particularly useful for biomedical applications. Some examples of useful biomedical applications include protein microarrays, cell microarrays, and DNA microarrays.
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申请公布号 |
US2005147994(A1) |
申请公布日期 |
2005.07.07 |
申请号 |
US20040979012 |
申请日期 |
2004.11.01 |
申请人 |
SANDFORD ANDREW F.;SUBRAMANIAN VENKITESWARAN;ALLEN JEFFREY R.;SWANSON PAUL E.;STORER JOEY W.;SHARMA DEEPAK K. |
发明人 |
SANDFORD ANDREW F.;SUBRAMANIAN VENKITESWARAN;ALLEN JEFFREY R.;SWANSON PAUL E.;STORER JOEY W.;SHARMA DEEPAK K. |
分类号 |
C08G18/10;C12N11/06;C12N11/08;G01N33/545;(IPC1-7):C12Q1/68;G01N33/53 |
主分类号 |
C08G18/10 |
代理机构 |
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