HLA-E CHIMERIC MOLECULE

摘要

It is intended to provide an HLA-E chimeric molecule which inhibits the cytotoxic activity of human NK cells in non-human mammalian cells; a base sequence encoding this chimeric molecule; a non-human mammalian cell transformed by this base sequence; and the corresponding mammal. The above-described HLA-E chimeric molecule is a peptide in which the signal peptide domain, the alpha1 domain and/or the alpha2 domain of HLA-E have been entirely or partly modified. The above-described base sequence is a base sequence encoding this chimeric molecule. A transformant having the above-described base sequence transferred thereinto has an effect of effectively expressing HLA-E.