发明名称 |
COMBINATION IL-2/ANTI-HERZ ANTIBODY THERAPY FOR CANCERS CHARACTERIZED BY OVEREXPRESSION OF THE HER2 RECEPTOR PROTEIN |
摘要 |
Methods for treating a subject with a cancer that is characterised by overexpression of HER2 receptor protein using a combination of interleukin-2 (IL-2) or biologically active variant thereof and at least one anti-HER2 antibody or antigen-binding fragment thereof are provided. These therapeutic agents are administered as two separate pharmaceutical compositions, one containing IL-2 (or variant thereof), which is administered according to a constant IL-2 dosing regimen or a two-level IL-2 dosing regimen, the other containing at least one anti-HER2 antibody (or fragment thereof), which is administered according to a weekly dosing regimen, or is administered once every two, three, or four weeks. Administering of these two agents together potentiates the effectiveness of the anti-HER2 antibody alone, resulting in a positive therapeutic response that is improved with respect to that observed with this therapeutic agent alone. |
申请公布号 |
WO03061571(A3) |
申请公布日期 |
2005.07.07 |
申请号 |
WO2003US01394 |
申请日期 |
2003.01.18 |
申请人 |
CHIRON CORPORATION;WOLIN, MAURICE, J.;MILAN, SANDRA |
发明人 |
WOLIN, MAURICE, J.;MILAN, SANDRA |
分类号 |
A61K9/19;A61K38/00;A61K38/20;A61K39/395;A61P35/00;A61P43/00;C07K16/32 |
主分类号 |
A61K9/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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