发明名称 |
METHOD OF OBTAINING TOLTERODINE |
摘要 |
<p>The invention relates to a method of obtaining tolterodine. The inventive method consists in: reacting a compound having formula (II), wherein R is a hydroxyl protective group and the asterisk indicates an asymmetric carbon atom, with diisopropylamine in the presence of a reducing agent; optionally, converting the resulting intermediate into a salt, and, if desired, isolating same; removing the hydroxyl protective group; and, if desired, separating the desired enantiomer (R) or (S) or the mixture of enantiomers and/or converting the compound thus obtained into a pharmaceutically-acceptable salt thereof. Tolterodine is a muscarinic receptor antagonist which can be used in the treatment of urinary incontinence and other symptoms of urinary bladder hyperactivity.</p> |
申请公布号 |
WO2005061431(A1) |
申请公布日期 |
2005.07.07 |
申请号 |
WO2004ES00572 |
申请日期 |
2004.12.21 |
申请人 |
RAGACTIVES, S.L.;PASCUAL COCA, GUSTAVO;MARTIN PASCUAL, PABLO;MARTIN JUAREZ, JORGE |
发明人 |
PASCUAL COCA, GUSTAVO;MARTIN PASCUAL, PABLO;MARTIN JUAREZ, JORGE |
分类号 |
C07C47/277;C07C213/02;C07C213/10;C07C217/62;(IPC1-7):C07C215/54;C07C213/08;C07C217/54;C07C47/27;C07C45/29;C07C45/58 |
主分类号 |
C07C47/277 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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