GENERATION OF LIVING TISSUE CONSTRUCTS IN VIVO USING A MOLD

摘要

The invention features methods of making living tissue constructs having a predetermined shape by obtaining a negative mold having a defined shape; suspending isolated tissue precursor cells in a hydrogel to form a liquid hydrogel­ precursor cell composition; filling the liquid hydrogel-precursor cell composition into the mold; implanting the filled mold into a living host for incubation; removing the mold after a suitable incubation period; and removing the living tissue construct from the mold. The final living tissue construct can then be surgically implanted into a patient.