| 发明名称 |
Derivados de pró-droga de 1,3-diamino-2-hidroxipropano |
| 摘要 |
"DERIVADOS DE PRó-DROGA DE 1,3-DIAMINO-2-HIDROXIPROPANO". A presente invenção refere-se aos compostos da fórmula (AA), (I) e (X) úteis em tratar doença de Alzheimer e outras doenças similares. Estes compostos incluem inibidores da enzima beta-secretase que são úteis no tratamento de doença de Alzheimer e outras doenças caracterizadas pela deposição de peptídeo beta A em um mamífero. Os compostos da invenção são úteis nas composições farmacêuticas e métodos de tratamento para reduzir formação de peptídeo beta A. |
| 申请公布号 |
BR0314071(A) |
申请公布日期 |
2005.07.05 |
| 申请号 |
BR20030314071 |
申请日期 |
2003.09.08 |
| 申请人 |
PHARMACIA & UPJOHN COMPANY LLC;ELAN PHARMACEUTICALS, INC. |
发明人 |
YVETTE FOBIAN;JOHN N. FRESKOS;BARBARA JAGODZINSKA |
| 分类号 |
C07D249/08;A61K31/165;A61K31/17;A61K31/18;A61K31/222;A61K31/223;A61K31/225;A61K31/341;A61K31/351;A61K31/352;A61K31/36;A61K31/381;A61K31/385;A61K31/4015;A61K31/4035;A61K31/4155;A61K31/4164;A61K31/4172;A61K31/4184;A61K31/4196;A61K31/421;A61K31/423;A61K31/426;A61K31/437;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/4425;A61K31/4439;A61K31/4453;A61K31/4465;A61K31/455;A61K31/47;A61K31/495;A61K31/4965;A61P9/00;A61P25/00;A61P25/02;A61P25/16;A61P25/28;A61P43/00;C07C69/80;C07C233/65;C07C237/06;C07C237/22;C07C255/29;C07C271/20;C07C271/22;C07C311/09;C07C317/44;C07C317/48;C07C317/50;C07C323/52;C07C323/58;C07C323/59;C07C323/60;C07D207/08;C07D207/12;C07D207/16;C07D207/26;C07D207/48;C07D209/08;C07D209/42;C07D209/46;C07D209/48;C07D211/42;C07D211/44;C07D211/62;C07D211/96;C07D213/30;C07D213/38;C07D213/51;C07D213/81;C07D213/82;C07D213/89;C07D215/50;C07D231/12;C07D231/14;C07D233/84;C07D233/90;C07D235/24;C07D237/04;C07D237/30;C07D241/24;C07D261/08;C07D261/18;C07D263/32;C07D263/48;C07D263/58;C07D277/20;C07D277/28;C07D277/30;C07D277/36;C07D277/56;C07D295/10;C07D295/185;C07D295/22;C07D307/20;C07D307/52;C07D309/12;C07D311/24;C07D317/30;C07D317/58;C07D319/06;C07D319/18;C07D333/20;C07D333/32;C07D333/34;C07D333/48;C07D401/04;C07D403/04;C07D409/04;C07D413/04;C07D471/04;(IPC1-7):C07C215/00 |
主分类号 |
C07D249/08 |
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