发明名称 |
Use of a lyophilizate of dedifferentiated plant cells, for depigmentation, lightening, protecting and regenerating the epidermis |
摘要 |
<p>Use, in a cosmetic or pharmaceutical composition (A), of at least one lyophilizate (B) of dedifferentiated plant cells, where (B) causes depigmentation and/or lightening, protection and regeneration of the epidermis. An independent claim is also included for topical cosmetic or pharmaceutical compositions that contain (B). ACTIVITY : Dermatological. Human keratinocytes and melanocytes were seeded on to polycarbonate filters and grown for 10 days at an air/medium interface to produce a type VI (negroid) epidermis. Samples of this were incubated for an unspecified time with a cream (PXTS; designed for very dry skin) that contained 0.5 % of a lyophilizate of dedifferentiated cells of Crithmum maritimum. Intracellular melanin synthesis was then analyzed spectrometrically at 475 nm; absorbance was 0.160 in a negative control but 0.101 (37 % reduction) in the test sample. A further test showed a 32 % reduction in tyrosinase activity. MECHANISM OF ACTION : Blocking activity of tyrosinase (depigmentation and lightening); scavenging free radicals (protective effect) and/or stimulating proliferation of cells in the basal layer and inhibiting epidermal differentiation (regenerative effect).</p> |
申请公布号 |
FR2864446(A1) |
申请公布日期 |
2005.07.01 |
申请号 |
FR20030015521 |
申请日期 |
2003.12.29 |
申请人 |
SECMA BIOTECHNOLOGIES MARINES |
发明人 |
MEKIDECHE NICOLE |
分类号 |
A61K8/97;A61K8/99;A61K36/00;A61P17/00;A61Q17/00;A61Q19/02;A61Q19/08;(IPC1-7):A61K35/78;A61K7/48 |
主分类号 |
A61K8/97 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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