发明名称 |
PROCESS FOR THE PREPARATION OF TERTIARY AMINES ATTACHED TO A SECONDARY CARBON CENTRE |
摘要 |
There is provided a process for the preparation of a compound of Formula: (1) wherein Ar represents an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group comprising an aromatic moiety; and R<1>, R<2> and R<3> each independently represent an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group; said process comprising: a) reducing a compound of Formula: (2) to form a compound of Formula: (3) b) activating the compound of Formula: (3) to form a compound of Formula: (4) wherein X represents a leaving group; and c) coupling the compound of Formula: (4) to a compound of Formula: (5) to form a compound of Formula: (1). Stereoselective processes are also provided. |
申请公布号 |
WO2005058804(A1) |
申请公布日期 |
2005.06.30 |
申请号 |
WO2004GB05199 |
申请日期 |
2004.12.08 |
申请人 |
AVECIA PHARMACEUTICALS LIMITED;FIELDHOUSE, ROBIN |
发明人 |
FIELDHOUSE, ROBIN |
分类号 |
C07C29/143;C07C209/14;C07C209/16;C07C269/06;C07C271/42 |
主分类号 |
C07C29/143 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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