发明名称 |
METHODS FOR THE PREPARATION OF A FINE CHEMICAL BY FERMENTATION |
摘要 |
The present invention features methods of increasing the production of a fin e chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides method s for the production of lysine by way of utilizing fructose or sucrose as a carbon source. |
申请公布号 |
CA2548125(A1) |
申请公布日期 |
2005.06.30 |
申请号 |
CA20042548125 |
申请日期 |
2004.12.17 |
申请人 |
BASF AKTIENGESELLSCHAFT |
发明人 |
ZELDER, OSKAR;KIEFER, PATRICK;KROGER, BURKHARD;KLOPPROGGE, CORINNA;HAEFNER, STEFAN;WITTMANN, CHRISTOPH;SCHROEDER, HARTWIG;HEINZLE, ELMAR |
分类号 |
C12P13/08;C12N1/21;C12N9/04;C12N15/53 |
主分类号 |
C12P13/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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