IMPROVED INTERFERON POLYMER CONJUGATES

摘要

COMPOSITIONS CONTAINING ALPHA INTERFERON CONJUGATED TO A SUBSTANTIALLY NON-ANTIGENIC POLYMER ARE DISCLOSED IN WHICH AT LEAST ABOUT 30% OF THE CONJUGATES INCLUDE COVALENT ATTACHMENT OF THE ALPHA INTERFERON TO THE SUBSTANTIALLY NON-ANTIGENIC POLYMER AT A HISTIDINE. ALSO DISCLOSED IS A PROCESS FOR PREPARING THE CONJUGATES. THE PROCESS INCLUDES CONTACTING AN ALPHA INTERFERON WITH A SUCCINIMIDYL CARBONATE-ACTIVATED SUBSTANTIALLY NONANTIGENIC POLYMER AT A PH WHICH IS SUFFICIENT TO FACILITATE COVALENT ATTACHMENT OF THE POLYMER ON A HISTIDINE OF THE ALPHA INTERFERON. (FIGURE 1)