发明名称 |
BIOSENSORS FOR DETECTING MACROMOLECULES AND OTHER ANALYTES |
摘要 |
Described are compositions and methods that are useful in the identification and quantification of any polypeptide or macromolecular complex using a set of co-aptamer constructs. Aptamer constructs are constructed that bind to uniqu e epitopes of a polypeptide of macromolecular construct. Those aptamer constructs contain an epitope binding site, a co-aptamer binding site, and a detectable label. In the presence of the cognate polypeptide, analyte- polypeptide complex, or other macromolecular complex, the co-aptamers associate with one another to produce a detectable signal. The co-aptamer constructs may be joined by a linker to produce a bivalent aptamer construct .
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申请公布号 |
CA2545006(A1) |
申请公布日期 |
2005.06.30 |
申请号 |
CA20042545006 |
申请日期 |
2004.12.10 |
申请人 |
SAINT LOUIS UNIVERSITY |
发明人 |
KNOLL, ERIC;HEYDUK, EWA;HEYDUK, TOMASZ |
分类号 |
C12Q1/68;A61K31/7088;A61K31/713;C07H21/00;C12N15/11;C12Q1/37;G01N;G01N21/64;G01N33/50;G01N33/53;G01N33/542;G01N33/58 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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