DOUBLE PELLET FORMULATION OF PROTON PUMP INHIBITORS AND CLARITHROMYCIN FOR THE TREATMENT OF GASTROINTESTINAL ULCER, AND METHOD FOR PRODUCING THE SAME

摘要

The present invention relates to a double pellet formulation effective for the treatment of various peptic ulcers, including a peptic ulcer caused by Helicobactor pylori, as well as a preparing method thereof. More particularly, the present invention relates to a double pellet formulation in which layers separated from each other are formed in one pellet, and a proton pump inhibitor and antibiotic clarithromycin are contained in the separated layers, respectively, such that upon administration of the formulation, the drugs can be released in different sites of the living body in a more stable form, thus maximizing a therapeutic effect against various peptic ulcers, including a peptic ulcer caused by Helicobactor pylori, as well as a preparing method thereof.