| 摘要 |
THE INVENTION THE COMPOUNDS OF FORMULA (I)FORMULA (I) AND PHARMECEUTICALLY ACCEPTABLE DERIVATIVES THEREOF IN WHICH:R° AND R1 ARE INDEPENDENTLY SELECTED FROM H, HALOGEN, C1-6ALKYL, C1-6ALKOXY, OR C1-6ALKOXY SUBSTITUTED BY ONE OR MORE FLUORINE ATOMS;R2 IS H, C1-6ALKYL, C1-6ALKYL SUBSTITUTE BY ONE OR MORE FLUORINE ATOMS, C1-6ALKOXY,C1-6 HYDROXYALKYL, SC1-6ALKYL, C(O)H, C(O)C1-6ALKYL,C1-6ALKYLSULPHONYL, C1-6ALKOXY SUBSTITUTED BY ONE OR MORE FLUORINE ATOMS; AND R3 IS C1-6ALKYL OR NH2. COMPOUNDS OF FORMULA (1) ARE POTENT AND SELECTIVE INHIBITORS OF COX-2 AND ARE OF USE IN THE TREATMENT OF THE PAIN, FEVER, INFLAMMATION OF A VARIETY OF CONDITIONS AND DISEASES.
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