PROAEROLYSIN CONTAINING PROTEASE ACTIVATION SEQUENCES AND METHODS OF USE FOR TREATMENT OF PROSTATE CANCER
摘要
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, The proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
申请公布号
WO03018611(A3)
申请公布日期
2005.06.30
申请号
WO2002US27061
申请日期
2002.08.23
申请人
UNIVERSITY OF VICTORIA INNOVATION AND DEVELOPMENT;JOHNS HOPKINS UNIVERSITY;DENMEADE, SAMUEL, R.;ISAACS, JOHN, T.;BUCKLEY, JAMES, THOMAS
发明人
DENMEADE, SAMUEL, R.;ISAACS, JOHN, T.;BUCKLEY, JAMES, THOMAS