(3,4-DISUBSTITUTED)PROPANOIC CARBOXYLATES AS S1P (EDG) RECEPTOR AGONISTS,申请号WO2004US41887-传众专利搜索

发明名称	(3,4-DISUBSTITUTED)PROPANOIC CARBOXYLATES AS S1P (EDG) RECEPTOR AGONISTS
摘要	<p>The present invention encompasses compounds of Formula A: A as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.</p>
申请公布号	WO2005058848(A1)	申请公布日期	2005.06.30
申请号	WO2004US41887	申请日期	2004.12.13
申请人	MERCK & CO., INC.;COLANDREA, VINCENT, J.;DOHERTY, GEORGE, A.;HALE, JEFFREY, J.;HUO, PEI;LEGIEC, IRENE, E.;TOTH, LESLIE;VACHAL, PETR;YAN, LIN	发明人	COLANDREA, VINCENT, J.;DOHERTY, GEORGE, A.;HALE, JEFFREY, J.;HUO, PEI;LEGIEC, IRENE, E.;TOTH, LESLIE;VACHAL, PETR;YAN, LIN
分类号	A61K31/506;A61K31/4245;A61K31/427;A61K31/443;C07D271/06;C07D285/12;C07D413/04;C07D413/10;C07D413/14;C07D417/04;(IPC1-7):C07D271/06;A61K31/424	主分类号	A61K31/506
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