发明名称 |
RECOMBINANT CATALYTIC POLYPEPTIDES AND THEIR USES |
摘要 |
The present invention provides a recombinant catalytic polypeptide for cleaving a target protein, the nucleic acid encoding the recombinant catalytic polypeptide, a cell hosting the nucleic acid encoding the recombinant catalytic polypeptide, and a non-human transgenic mammal that is capable of producing a heterologous antibody with proteolytic activity. The invention also provides methods of cleaving a target protein using the recombinant catalytic polypeptides both in vitro and in vivo. The invention further provides a library of recombinant catalytic polypeptides with altered enzymatic activity and a method to alter enzymatic activity of the recombinant catalytic polypeptides. |
申请公布号 |
WO2004033658(A3) |
申请公布日期 |
2005.06.30 |
申请号 |
WO2003US32214 |
申请日期 |
2003.10.09 |
申请人 |
INTEGRIGEN, INC.;SMIDER, VAUGHN;LARRICK, JAMES, W. |
发明人 |
SMIDER, VAUGHN;LARRICK, JAMES, W. |
分类号 |
C07K16/22;C07K16/24;C07K16/26;C12N9/00 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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