| 摘要 |
The present invention relates to methods and reagents for [<SUP>18</SUP>F]-fluorination, particularly of peptides. The resultant <SUP>18</SUP>F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula <SUP>18</SUP>F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI): <?in-line-formulae description="In-line Formulae" end="lead"?><SUP>18</SUP>F-(CH<SUB>2</SUB>CH<SUB>2</SUB>O)<SUB>n</SUB>-(CH<SUB>2</SUB>)<SUB>m</SUB>-SH (IV) <?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?><SUP>18</SUP>F-(CH<SUB>2</SUB>)<SUB>p</SUB>-SH (V) <?in-line-formulae description="In-line Formulae" end="tail"?> may be reacted with an activated peptide as a means for <SUP>18</SUP>F-labelling.
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