THERAPEUTIC AGENT FOR TREATING ANXIETY NEUROSIS OR DEPRESSION

摘要

A therapeutic remedy for anxiety neurosis or depression is disclosed which contains an MC4 receptor antagonist as the active ingredient; and, in particular, a piperazine derivative represented by the formula [1] [wherein Ar<1> is a phenyl group, a substituted phenyl group, a naphthyl group or a substituted naphthyl group; Ar<2> is a naphthyl group, a substituted naphthyl group, a quinolyl group, a group represented by the formula: (wherein R<4> is a hydrogen atom or a halogen atom; and X-Y is CH-NH, CH-O, CH-S, or N-O), or a group represented by the formula (wherein R<5> is a hydrogen atom, hydroxy, or C1-10 alkoxy); R<1> is a hydrogen atom, C1-10 alkyl group, a C3-8 cycloalkyl group, a C3-10 alkenyl group, a phenyl group, a 1-cyanoethyl group, a pyrimidin-2-yl group or an amidyl group; R<2> and R<3> are the same or different, and are each a hydrogen atom or a C1-10 alkyl group; A-B is N-CH2, CH-CH2, C(OH)-CH2 or C=CH; T<1> is a single bond, -N(R<6>)- (wherein R<6> is a hydrogen atom or a C1-10 alkyl group), -O-, -CH=CH- or -C(=O)-; n is an integer of from 1 to 10 when T<1> is a single bond, -CH=CH- or -C(=O)-, and n is an integer of from 2 to 10 when T<1> is -N(R<6>)- or -O-], or a pharmaceutically acceptable salt thereof.