AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION

摘要

Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula (I) the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; wherein G is a direct bond or C1-10alkanediyl optionally substituted with one or more hydroxy, C1-6alkyloxy, Ar<1>Cl-6alkyloxy, C1-6alkylthio, Ar<1>C1-6alkylthio, HO(-CH2-CH2-O)n-, C1-6alkyloxy(-CH2-M2-O)n- or Ar<1>Cl-6alkyloxy(-CH2-C2-O)n-; R<1> is Ar<1> or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C1-4alkyl)amino; one of R<2a >and R<3a> is selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar<2>, N(R<4a>R<4b>), N(R<4a>R<4b>)sulfonyl, N(R<4a>R<4b>)carbonyl, C1-6alkyloxy, Ar<2>oxy, Ar<2>C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or -C(=Z)Ar<2>; and the other one of R<2a> and R<3a >is hydrogen; in case R<2a> is different from hydrogen then R<2b >is hydrogen, C1-6alkyl or halogen and R<3b> is hydrogen; in case R<3a >is different from hydrogen then R<3b >is hydrogen, C1-6alkyl or halogen and R<2b >is hydrogen. Compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.