Variant polypeptides containing plekstrin homology domains and uses therefor

摘要

The instant invention provides polypeptides comprising variant pleckstrin homology (PH) domains. The invention provides polypeptides having increased or decreased binding specificity for a phosphatidylinositide molecule to which the PH domain naturally binds. Further, the invention provides polypeptides having increased binding specificity for a phosphatidylinositide molecule to which the PH domain naturally does not bind.