LSA-5 LIVER STAGE AND BLOOD STAGE ANTIGEN OF PLASMODIUM FALCIPARUM, IMMUNOGENIC COMPOSITION COMPRISING SAID ANTIGEN, AND VACCINES AGAINST MALARIA

摘要

The present invention pertains to the protection against malaria. More particularly, the invention is based on the characterization of a novel live r and sporozoite-stage P. falciparum antigen, referred to as LSA-5. This antig en is highly antigenic and the prevalence of antibodies in subjects living in endemic areas is extremely high (ca. 90 %). The invention concerns antigenic peptides, mixtures thereof, or polypeptides, mixotopes and conjugates comprising part of the sequence of LSA-5, as well as immunogenic composition s, vaccines and kits comprising these.