| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an intercellular adhesive polypeptide having low immunogenicity. <P>SOLUTION: The polypeptide (P) which expresses intercellular adhesiveness has the smallest amino acid sequence (X) and an auxiliary amino acid sequence (Y), and a number average molecular weight of 1,500-15,000. Preferably, (X) is at least one kind selected from Arg Gly Asp sequences, Leu Asp Val sequences, amino acid sequences represented by sequence Nos. (1) to (10), Leu Arg Glu sequences, His Ala Val sequences, and Tyr Lys Leu Asn Val Asn Asp Ser sequences (11), and Y has (Gly Ala)a sequences, (Gly Ala Gly Ala Gly Ser)b sequences, (Gly Ala Gly Ala Gly Tyr)c sequences, (Gly Ala Gly Val Gly Tyr)d sequences, (Gly Ala Gly Tyr Gly Val)e sequences, äAsp Gly Gly(Ala)fGly Gly Ala}g sequences, (Gly Val Pro Gly Val)h sequences, (Gly Val Gly Val Pro)m and/or (Gly Pro Pro)n. <P>COPYRIGHT: (C)2005,JPO&NCIPI |
