| 发明名称 |
THERAPEUTIC AGENT FOR ACUTE LEUKEMIA BY AML1 ACTIVATOR AND ITS USE |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain a differentiation inducer for a leukemic cell and a therapeutic agent against leukemia, containing the differentiation inducer. <P>SOLUTION: The function of an AML (acute myeloma leukemia) 1 complex is activated by phosphorylation of AML1 protein. Specific protein phosphorylating enzyme AML1K controls phosphorylation of AML1 protein. An AML1K activator is considered to induce differentiation of leukemic cell by activating an ALM1 complex through phosphorylation of AML1 protein. <P>COPYRIGHT: (C)2005,JPO&NCIPI |
| 申请公布号 |
JP2005170843(A) |
申请公布日期 |
2005.06.30 |
| 申请号 |
JP20030412711 |
申请日期 |
2003.12.11 |
| 申请人 |
NATIONAL CANCER CENTER-JAPAN;PHARMACEUTICALS & MEDICAL DEVICES AGENCY |
发明人 |
KITABAYASHI KAZUO |
| 分类号 |
G01N33/50;A61K31/35;A61K31/661;A61K35/76;A61K38/45;A61K45/00;A61K48/00;A61P35/02;A61P43/00;C12N9/12;C12N15/09;C12Q1/02;C12Q1/48;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
G01N33/50 |
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